cathepsin k造句

• Of these hydrolytic enzymes, cathepsin K is of most importance.
• Cathepsin K inhibitors show great potential in the treatment of osteoporosis.
• Cathepsin K has an optimal enzymatic activity in acidic conditions.
• Cathepsin K is degraded by Cathepsin S, called Controlled Cathepsin Cannibalism.
• Cathepsin K has also been found to be over-expressed in glioblastoma.
• Cathepsin K antibodies are marketed for research into expression of this enyzme by various cells.
• That the expression of Cathepsin K is characteristic for some cancers and not others has been documented.
• Very small amounts of enzymatic activity can be elucidated and is capable of resolving a femtomole of cathepsin K activity.
• There are, however, exceptions such as cathepsin K, which works extracellularly after secretion by osteoclasts in bone resorption.
• Cathepsin K is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness.
• Cathepsin K is a protease, which is defined by its high specificity for kinins, that is involved in bone resorption.
• Merck had a Cathepsin K inhibitor in Phase 3 clinical trials by the name of odanacatib for an expected indication of osteoporosis.
• Within these intercellular vesicles, cathepsin K, along with reactive oxygen species generated by TRAP, further degrades the bone extracellular matrix.
• Cathepsin K transmigrates across the ruffled border by intercellular vesicles and is then released by the functional "'secretory domain " '.
• While the proform of cathepsins are generally stable, once activated, proteases such as cathepsin K are vulnerable to inactivation in neutral pH environments.
• Several other cathepsins are expressed in osteoclasts including cysteine and aspartic proteases is generally unknown within bone, and they are expressed at much lower levels than cathepsin K.
• Upon polarization of the osteoclast over the site of resorption, cathepsin K is secreted from the "'ruffled border "'into the "'resorptive pit " '.
• The secretion of IL-6 by bone marrow stromal cells ( BMSC ) and the secretion of the adhesion molecules VCAM-1, ICAM-1 and adhesion molecules paramount to osteoclast activation, decrease the formation of the cells that form osteoclasts and downregulate cathepsin K, an important cysteine protease expressed in osteoclasts.